Across 1,374 ranked games on patch 16.21 in Master and above, Twisted Fate mains win 53.7% of their games in the mid lane.
Their most common build appears in 43.4% of those games and wins 54.4% of its 597 games.
It starts
Doran's Ring and
two Health Potions, completes
Rod of Ages,
Lich Bane,
Rapid Firecannon and
Zhonya's Hourglass in that order, and takes
Boots of Swiftness.
Three other builds are played often enough in the mid lane to be measured on their own.
In the mid lane, Twisted Fate mains fare best against
Mel (won 90.9% of 11 games),
Vladimir (won 75.0% of 16 games) and
Akali (won 67.7% of 31 games).
Their hardest matchups, the champions that counter Twisted Fate, are
Katarina (won 26.7% of 30 games),
Akshan (won 29.4% of 17 games) and
Yasuo (won 38.1% of 21 games).